Prozac, the Drug of Choice in Happy Valley
In 1946,
W. H. Auden wrote The Age of
Anxiety, a pre-Prozac psychological, perhaps psycho-historical book
length poem to characterize society following the deadliest war in
history and the perfectly normal feelings relative to the uncertainness
of the present and immediate future.
Harry S. Truman signed the National Mental Health Act (1946), which
called for the establishment of a National Institute of Mental Health
(NIMH). Its first meeting, the Advisory Mental Health Council (NAMHC),
was convened on August 15, 1946, financed by the Greentree Foundation.
On April 15, 1949, an official formally established the NIMH which,
according to its web site, its vision is “a world in which mental
illnesses are prevented and cured.” Its mission is, “to transform the
understanding and treatment of mental illnesses through basic and
clinical research, paving the way for prevention, recovery and cure.”
[1] The NIMH is just an “aggressive
extension of the pharmaceutical industry.
The National Institute of Mental Health
says, statistically, that about twice as many women as men
experience depression. Utah leads the country in the use of narcotic
painkillers such as codeine and morphine-based drugs. It is ranked
seventh in total prescriptions.
[2] Well, of course, women in Utah
experience depression; it is not a medical condition; there is no
scientific way, like a blood test, to diagnose a chemical imbalance.
Mormon women, not just in Utah, have much about which to feel depressed.
It does not require a rocket scientist to discover that. Experiencing
happiness, sadness, pain, depression is part of humanity, not an
illness.
In the 1970s, psychiatry was faltering and
psychiatric drug sales were decreasing. The
American Psychiatric
Association (APA), then engaged in a “rebranding” campaign, and
promoted its devised “diseases” in the
DSM-III, insinuating that
they were biologically similar to diabetes and the drug industry
compared its psychiatric chemicals to insulin. The industry concocted
and promoted the idea of a chemical imbalance within the brain, which,
with massive drug-industry-funded campaigns and political support, the
public gradually accepted, making it easy for the pharmaceutical
companies to increase their market share.
[3] It is scientifically impossible
to calculate the “levels of any biochemical in the tiny spaces between
nerve cells (the synapses) in the brain of a human being.”
Rhetoric about “biochemical imbalances” is nothing but marketing
devised to sell psych drugs.
[4]
Beginning in the 1980s, there were hundreds of
articles “about depression in both medical journals and
general-readership magazines.”
[5] In 1987, Lew Judd, the NIMH
director (1987-1990), said, “By making these materials on depressive
illness available, accessible in physicians’ offices all over the
country, important information is effectively reaching the public in
settings which encourage questions, discussion, treatment, or referral.”
Eli Lilly financed DART’s publication of eight million brochures,
Depression: What You Need
to Know, along with 200,000 posters.
[6]
In 1988, after lots of preparation, the NIMH
conducted its DART (Depression
Awareness Recognition and Treatment)
campaign, with a $750,000
budget, to brainwash the public into believing that undiagnosed
depression was a common affliction that needed medication. Upjohn and
the APA, almost a third of its annual budget of $62 million comes from
big pharma, informed the public about “panic disorder.” Judd created the
psychiatric marketing strategy,
Decade of the Brain, signed into law by a Presidential Proclamation.
In 1990, the NIMH introduced its clever tactic accompanied by the new
SSRI drugs “touted as safer and more effective than older
antidepressants because they balanced out the chemicals in the brain
that, imbalanced, caused mental illness.”
[7]
On July 17, 1990, President George H. W. Bush,
formerly a board member at Eli Lilly, signed a Presidential Proclamation
confirming House Joint Resolution 174 that declared 1990 the first year
of the Decade of the Brain,
launched on January 1, 1990.
[8] In conjunction with the
Decade of the Brain, the
NIMH, the Library of
Congress (LC) and the NIH published at least three books and
sponsored numerous activities such as congressional breakfasts and
convened several conferences, beginning on July 24, 1991, with
Frontiers of Neuroscience. All
of these activities were designed to introduce members of
Congress, their staffs, and the general public to “cutting-edge research
on the brain.”
[9]
The aggressive marketing campaign was to persuade
the public that twenty percent of the population had a mental disorder
and might require psychiatric medications. Industry-funded psychiatric
support groups began encouraging “screening programs,” in an effort to
recruit new consumers.
[10]
In a nationwide study of 900,000 children, the number of children taking
the drugs had tripled between 1987 and 1996.
Additionally, prescriptions for
antidepressants, like Prozac, had increased.
[11] With psych drugs,
the SSRIs like Prozac are useless, expensive and extremely dangerous. It
is essentially Russian roulette for the patient. The only benefactor is
the drug industry which makes billions of dollars.
[12]
“Biopsychiatric treatments exert their therapeutic
effect by impairing higher human functions, including emotional
responsiveness, social sensitivity, self-awareness or self-insight,
autonomy, and self-determination. More drastic effects include apathy,
euphoria and mania, and lobotomy-like indifference.” This occurs
primarily in the “frontal lobe, limbic system, and other structures.”
Dr. Peter R. Breggin said that “these effects occur with the SSRI
antidepressants, such as Prozac, Zoloft, and Paxil; the stimulants, such
as Ritalin, Concerta, and Adderall; and the newer antipsychotics, such
as Risperdal and Zyprexa.”
[13]
According to a 2006 study by one of the largest
prescription companies, Utah residents were more likely to take
antidepressants than the rest of the American population. Some people
suggest that this had something to do with religion. Utah was then the
second most religious state in America where nearly 20% of the
population is on some kind of an antidepressant. Not only did Utah
residents, particularly women, consume the most antidepressants, they
were also on the list of top-ten most medicated states. Additionally,
people who had health insurance were more likely to be on
antidepressants. One-fifth of the insured women in Utah were on
antidepressants in 2005.
[14]
The Utah Department
of Health's Health Data Committee released a report in 2010, the
Antidepressant Use in Utah
Report. It data came from the 2009 pharmacy claims for 899,323
insured residents of Utah ages 18 to 64.
The report did not include those on Medicaid or Medicare or the
uninsured. People with insurance are more likely to seek treatment for
depression and other issues. It is quite possible that “women in
northern Utah are diagnosed with more chronic diseases.” The study
indicated that doctors prescribe antidepressant drugs for patients
diagnosed with two or more “significant chronic diseases… Fifty-two
percent of people who have three significant chronic diseases are
prescribed antidepressants.”
[15]
Dr. Curtis Canning,
president of the Utah Psychiatric Association, with a practice in Logan,
suggests, “In Mormondom, there is a social expectation particularly
among the females, to put on a mask, say 'Yes' to everything that comes
at her and hide the misery and pain. I call it the 'Mother of Zion'
syndrome.” Further, Canning says, “Obedience, conformity and maintaining
a sense of harmony are unspoken but widely recognized behaviors, which
all contribute to what he calls ‘the Mother of Zion syndrome.’”
[16]
The church expects
and in some cases demands public perfection, despite what is going on
behind closed doors. It’s the public persona and a smile at all times
that matters! Women in the church were once expected to have a gaggle of
children, bake bread, can fruit and veggies, maintain a garden, make
their own clothes as well as their children’s, be politically active (if
you are pro-war and Republican), work on their family history, keep a
journal, obey their priesthood-holding husbands who might be virtuous,
smiling, glad-handing guys at church while tyrannizing his family at
home. Moreover, if you don’t have sufficient children of your own, then
participate in what was called the Lamanite Placement Program. Besides
that, members are supposed to accept any and every calling because,
after all, it is a request from God himself. Yeah, for women, there is a
lot of pressure to be perfect, no beyond perfect, angelic.
Mental Health America, an independent mental health
advocacy group, ranked Utah the most depressed state in America. In
2002, Express Scripts, the largest pharmacy benefit management (PBM)
organization in the United States, with 2013 revenues of $104.62
billion, revealed that Utah residents “were prescribed antidepressant
drugs more than those of any other state and at twice the national
average.” Seventy percent of the residents in Utah are Mormon which
caused some consternation about the church’s responsibility in the
mental health of its members and their dependence on antidepressants
such as Prozac and Zoloft.
[17]
Deseret News
reported that Professor Daniel K. Judd, a professor at BYU had
researched the reasons for the high antidepressant use in Utah. He
asserts that the LDS Church is not to blame but claims, “Perhaps one of
the reasons the residents of Utah lead the nation in the use of
antidepressants is that since they are generally more educated and aware
of the symptoms and treatments of depression, they are more likely than
the residents of other states to seek medical treatment.”
[18] The LDS Church owns BYU.
Professors must be active members of the church, must have a current
temple recommend and are underpaid compared to other universities. BYU
professors understand who and to what they must show their allegiance.
Just ask Michael Quinn about his experience or the husband of Martha
Nibley Beck, the daughter of Hugh Nibley. Judd was obligated to
exonerate the LDS Church from all responsibility.
Dr. Judd also suggests that LDS members in Utah
“might more readily turn to the medical profession for help because the
church advises members not to use alcohol and tobacco. Research
indicates Latter-day Saints in Utah and elsewhere are less likely to
self-medicate, Judd said, with those drugs or illegal drugs.” He did
admit that the Mormon culture is fraught with “an attitude of
perfection.” “LDS Apostle Joseph B. Wirthlin taught in General
Conference, You can keep [God’s] commandments by continually striving to
do so. Does that mean all of God’s commandments?” you might ask. Yes!
All of them! (Ensign, November 1999, page 40)” There is a
legitimate reason why Utah, seventy percent Mormon, leads the nation in
antidepressant use.
[19]
As of April 2014, the number of people taking
psychiatric drugs in the United States is as follows:
ADHD drugs:
10,291,860
Antidepressants:
41,226,394
Antipsychotics:
6,845,303
Anti-anxiety
36,472,663
All Psychiatric drugs:
78,694,222 total
[20]
In addition to producing brain dysfunction,
prescribing drugs or any physical intervention seems to “reinforce the
doctor’s role as an authority and the patient’s role as a helpless sick
person.” The doctor, an authority figure, tells the subservient
obedience-trained patient that he/she has a disorder but with the
assistance of the doctor, and by adhering to his instructions, the
patient will recover.
From 2012 to 2014, the suicide rate in Utah was
20.8 per 100,000 individuals for an
average of 557 suicides per year, on the highest in the nation.
In 2014, in Utah, suicide was the
“leading cause of death for people ages 10 to 17 and 18-24” and the
“second leading cause of death for ages 25 to 44 and the fourth-leading
cause of death for ages 45-64.” Suicide
is the eighth leading cause of death for Utah residents from the age of
ten and up.
[21]
In addition to completed suicides, “more people are hospitalized
or treated in an emergency room for suicide attempts than are fatally
injured.” In 2013, hospitals treated thirteen Utah residents for
self-inflicted injuries every day (3,181 emergency department visits and
1,508 hospitalizations). The 2013 Youth Risk Behavior Survey indicated
that in the previous twelve months prior to the survey that Utah high
school students stated, 25.7% felt sad or hopeless, 15.5% seriously
considered committing suicide, 12.8% devised a suicide plan, 7.3%
attempted suicide one or more times and 2.1% of these students suffered
an injury, poisoning, or an overdose that had to be treated by a doctor
or nurse. The 2015 Prevention Needs Assessment data show that Salt Lake
County and Tooele County Health District students had higher rates of
psychological distress.
[22]
View the above
CDC-generated Suicide Rate Graphic
here.
Prozac, a Blockbuster of a Killer
SSRIs – Engineered Psychosis
(this is an amended version of a
chapter from my Sandy Hook book)
Fluoxetine, known under the
trade names
Prozac,
Sarafem,
Ladose and
Fontex, among others
(about 175), created in 1974, is an antidepressant of a class of
drugs called selective serotonin reuptake inhibitors (SSRIs). It was one
of the first therapies in its class used to treat what people called
clinical depression. It theoretically blocks the uptake of serotonin
within the human brain. By 2010, doctors would prescribe it to more than
fifty-four million people worldwide.
A blockbuster is a pill with an enormously high
sales quota, one that might be sold a billion times and represent a
gigantic sales volume. It might temporarily relieve the symptoms but
that is “secondary,” as many people feel ill and there are many
illnesses. Nevertheless, “illness is the exception and not the rule.
Consequently, sick people represent a relatively small market.”
[23] John Virapen wrote,
“Imagine if you could talk those who aren’t ill into taking pills. Then
you would reach a new dimension of marketing. That is the new quality of
a blockbuster.” That “was exactly the role Fluoxetine was supposed to
play.”
[24]
In 1975, Henry Gadsden, the head of Merck, one of
the world's largest drug companies, told
Fortune magazine that he
wanted Merck to be more like chewing gum maker Wrigley's. It had long
been his dream to make drugs for healthy people so that Merck could
“sell to everyone.” His dream now drives the marketing machinery of the
most profitable industry on earth. Drug companies are systematically
working to widen the very boundaries that define illness, and the
markets for medication continually grow ever larger.
[25]
Eli Lilly sells its products in approximately 125 countries. It was the
first company to mass-produce penicillin, the Salk polio vaccine, and
insulin, including human insulin using recombinant DNA. Lilly is the
world’s largest manufacturer and distributor of psychiatric medications
including Cialis, Cymbalta, Gemzar, Methadone, and Prozac.
[26]
By 1984, Eli Lilly was well aware of the serious
issues with Prozac, long before it was introduced to the American
market. Statistics in an internal Lilly document show that akathisia, a
severe agitation that often provokes suicide, occurs in at least one
percent of all patients. Lilly lists akathisia in its product literature
deigned for the United States, but only as an infrequent event for
Prozac users and fails to mention akathisia and its relationship to
suicide.
Internal documents explain why German regulators
refused to approve Prozac without a stronger suicide warning. On May 25,
1984, Barbara von Keitz, an Eli Lilly employee in Hamburg sent a
document to Lilly headquarters in Indianapolis, regarding Prozac. She
said that studies conducted by Eli Lilly stated that Prozac compared to
standard antidepressants and placebo was ineffective. She pointed out
that there were sixteen suicide attempts during the treatment with
Prozac, two of which were successful. This was after Lilly excluded
anyone who was at risk for suicide from the studies. She suggested that
the suicides could probably be “attributed” to the drug. She pointed out
that the number of patients was too small and many of the studies were
incomplete as patients dropped out due to the high incidence of adverse
side effects.
[27]
On March 23, 1985, Dr. Richard Kapit, after his
safety review of Prozac, said in an internal FDA document that there
were seventy-six “significant” adverse events occurring among patients
exposed to Prozac in the clinical trials. Those side effects included:
hypersensitivity, psychotic episodes, and a decrease in hemoglobin
level. This drug caused nausea, insomnia, nervousness, diarrhea, a
reduced appetite and weight loss. Depression often affects appetite but
Prozac intensifies anorexia and weight loss. Other adverse reactions
experienced during the trials included seizures, paranoia, severe
dystonic reaction, scaly rash, mania, suicide, attempted suicide, and
movement disorders such as dyskinectic jaw movements, involuntary
movements of the face and arms, vaginal bleeding and allergic skin
reactions requiring hospitalization.
[28]
Dr. Kapit wrote, “Unlike standard tricyclic
antidepressants, fluoxetine’s (Prozac) profile of adverse effects more
closely resembles that of a stimulant drug than one that causes sedation
and gain of weight…Indeed nervousness was the most common adverse
symptom cited by long-term fluoxetine patients who eventually
discontinued therapy due to an adverse reaction.” Dr. Kapit said, “It is
possible that these adverse effects of fluoxetine treatment may
negatively affect patients with depression.” He continued, “It may be
appropriate to develop advisory labelling warning the physician that
certain signs and symptoms of depression may be exacerbated by this
drug. If the drug is marketed, post marketing studies should be required
to determine the frequency with which fluoxetine may cause
intensification of these specific signs and symptoms of depressive
illness.”
[29]
In the clinical trials, Prozac caused mania in one
in 100 people which would be much higher in unobserved patients in daily
life. One in 100, considered common, poses an incredible risk to public
safety. The newer antidepressants, the SSRIs, are four times more likely
to cause mania than the older antidepressants. Dr. Peter R. Breggin
states, “Seventy percent of the patients who became manic on Prozac had
never shown any signs of manic tendencies in the past.”
[30]
On October 10, 1985, the Psychopharmacologic Drugs
Advisory Committee (PDAC) convened a two-day public hearing to determine
the efficacy of Prozac (on the first day) and Haloperidol (on the second
day). According to the FDA regarding its Psychopharmacologic Drugs
Advisory Committee, “The
Committee shall consist of a core of 11 voting members including the
Chair…selected by the Commissioner…from among authorities knowledgeable
in the fields of psychopharmacology, psychiatry, epidemiology…and
related specialties. The core of voting members may include one
technically qualified member…who is identified with consumer interests.
[31] The composition of the committee
did not meet the FDA criteria in that there were seven employees of Eli
Lilly who participated.
Lilly knew Prozac’s stimulating effects, due to the
clinical trials, before the company marketed the drug. Charles M.
Beasley, a Lilly executive, compiled a secret report,
Activation and Sedation in
Fluoxetine Clinical Studies. He totaled the number of patients who
exhibited “nervousness, anxiety, agitation, insomnia.” He discovered
that thirty-eight percent of them experienced these adverse effects
during the brief clinical trials. Lilly never revealed the results of
Beasley’s report to the FDA or any other entity. Lilly concealed the
data until it was discovered in some company files. Many patients
actually left the trials due to the drug’s stimulating effect, leading
to the Prozac trials failure.
[32]
Dr. Ray W. Fuller issued the following in-house secret order, “Some
patients have converted from severe depression to agitation within a few
days (of starting Prozac). In future studies, the use of benzodiazepines
(tranquilizers) to control agitation will be permitted.” The FDA
prohibits the use of tranquilizers in conjunction with Prozac in the
clinical trials. The addictive tranquilizers, only to be taken for a
brief period, masked Prozac’s propensity to cause stimulation.
[33]
In 1962, the law stated that the FDA should not
approve of a drug if “there is a lack of substantial evidence that the
drug will have the effect it purports or is represented to have, under
the conditions of use prescribed, recommended or suggested in the
proposed labeling.”
[34] Dr. Robert S. Mendelsohn
wrote, “It doesn’t make much sense to buy a drug when the manufacturer
can’t prove that it works.”
[35]
Research
in the late 1980s, conducted by Eli Lilly confirmed that Prozac may
cause suicide. Yet, many doctors prescribed it to their patients
supposedly to prevent depression and suicide. Lilly evaluated its
clinical trials, which they claim involved more than three thousand
patients. They published their results in the
British Medical Journal (BMJ)
alleging that there was no increased suicide risk. Yet, even within the
article, it states that there were six suicides out of 1,765 patients on
Prozac as opposed to one in the 569 patients on placebo.
[36] The general public
typically does not read medical journals.
In 1986, in the clinical trials, 12.5 patients out of 1,000 who were
taking Prozac committed suicide as compared to only 3.8 patients who
were taking the non-SSRI antidepressants and 2.5 patients who were
taking a placebo. In 1995, in another trial for Prozac, the suicide rate
would be six times higher. Package inserts mention suicide, but not all
of the other possible adverse reactions. Suicide was not on the insert
for years even though Eli Lilly knew of the risk.
[37]
Eventually, the FDA found out about Eli Lilly’s
deadly deceptions. Because the company had spent millions of dollars, it
would be a “financial catastrophe” if the FDA failed to approve of
Prozac, which was ineffective, without the use of a tranquilizer. The
FDA, to rescue Eli Lilly, included those trials where the patients used
tranquilizers and manipulated the statistical data regarding the drug’s
effectiveness and “Prozac squeaked through.” No one informed the medical
profession, the unsuspecting potential patients or the public.
[38]
Incredibly, the FDA approved of Prozac using only
three cherry-picked favorable protocols, involving seventeen studies and
several hundred patients. Dr. Breggin thoroughly examined each of the
seventeen studies to determine exactly how many Prozac patients actually
finished the four, five, or six-week trials. The total number of
patients was (drum-roll here) was a paltry 286 patients. Out of
the thousands who initially offered to participate in the clinical
trials, less than 300 patients completed the trial. Based on the
conclusions of the predisposed questions of the doctors monitoring those
patients, the FDA approved Prozac on December 29, 1987 for treating
depression. Anyone taking Prozac, for more than a few weeks is actually
participating in a continuous clinical trial due to the failure of the
FDA to require legitimate, reasonably-timed trials that actually test
long-term usage, effectiveness and safety.
[39]
In January 1988, the month that Eli Lilly
introduced Prozac, people reported events “describing fluoxetine-induced
violence against self and others.” In May 1990, the FDA mandated that
Eli Lilly add “suicidal ideation” and “violent behaviors” to the
Post-introduction Reports section of its label.
Antidepressants and other psychiatric drugs can
contribute to marital conflicts, manic-like thoughts, paranoia, violent
impulses, and abnormal, irrational, bizarre, and destructive behavior.
[40] All antidepressants,
including the SSRIs, can cause mania. It has been fully documented that
Prozac can cause mania in patients who have previously never experienced
or had any tendencies toward mania. According to the APA’s
DSM IV (1994), “Symptoms like
those seen in a Manic Episode may also be precipitated by antidepressant
treatment such as medication.” The
DSM clarifies that mania is
frequently associated with violence and other criminal acts. The
psychotic behavior can be “goal-directed.” It states that patients often
display “irritability, particularly when the person’s wishes are
thwarted.”
[41]
By 1994,
out of fifty-four million people worldwide who took Prozac, the FDA
revealed that it had received 30,000 adverse event reports, including
more than 1,700 deaths. Out of those deaths, 1,100 committed suicide,
while another 1,900 attempted suicide. Almost ten percent of the total
adverse drug events (ADEs) from those taking Prozac were suicides and
suicide attempts. In spite of those 30,000 reports, the FDA did not
demand “black box” warnings on Prozac or other antidepressants for
thirteen years.
[42]
In 1998, the FDA commissioned a survey that discovered that doctors had
prescribed Prozac for infants 3,000 times.
In 1985, American sales of antidepressants and
antipsychotics had totaled $503 million. In 1987, Eli Lilly had $2.3
billion in its pharmaceutical division. In January 1988, Eli Lilly began
selling Prozac. By 1992, it was the company’s first billion-dollar drug.
By 1998, Zyprexa was Eli Lilly’s second billion-dollar drug. By 2000,
Eli Lilly was bringing in revenues of $10.8 billion just on those two
drugs. In 2008, the sales of antidepressants and antipsychotics would
total $24.2 billion, almost fifty times greater. Anti-psychotics even
outsold cholesterol-lowering medications. Worldwide sales of all
psychotropic drugs reached $40 billion.
[43] In 1999, Prozac produced
one-quarter of the company’s $10 billion in revenue. In the United
States, Prozac, Zoloft, and Paxil have sales surpassing $4 billion per
year. In 2000, Eli Lilly claimed that thirty-five million worldwide had
taken Prozac, their blockbuster drug.
[44]
The SSRI class of drugs, including Prozac, Zoloft,
Paxil, Celexa, and Luvox, cause violence, suicide, and psychosis. Even
the FDA admits that people were reporting a disproportionately high rate
of violence with Prozac.
[45] People erroneously believe
that psychiatric drugs are safe yet many people become suicidal,
aggressive and out of control and never realize it was or is caused by
the drugs.
[46]
The FDA approved Paxil for the treatment of “social
anxiety disorder,” a supposedly incapacitating form of shyness.
[47] Bioethicist Carl Elliott
said, “The way to sell drugs is to sell psychiatric illness. If you are
Paxil and you are the only manufacturer who has the drug for social
anxiety disorder, it’s in your interest to broaden the category as far
as possible and make the borders as fuzzy as possible.” Barry Brand,
Paxil’s product director, told the journal
Advertising Age, “Every
marketer’s dream is to find an unidentified or unknown market and
develop it. That’s what we were able to do with social anxiety
disorder.” [48]
In August 2001, Eli Lilly lost its U.S. patent
protection for Prozac and in January 2002, the Supreme Court rejected
Lilly's final appeal, a decision that allows other companies to make
generic versions of the drug. Currently, there are twenty companies that
make a generic version. Prozac, America’s “lifestyle drug,”
[49] now rebranded as
Sarafem in the United
States, has given rise to a number of comparably functioning
therapies for the treatment of clinical depression and other central
nervous system disorders such as obsessive compulsive disorder, bulimia
nervosa, and panic disorders.
Pharmaceutical companies make even more money by
promoting the off-label prescribing of drugs, at frequently higher
doses. This is incredibly dangerous for people residing in a nursing
home as older people do not metabolize drugs as quickly as they did when
they were younger. Almost 2.5 million Medicaid patients in nursing
homes, according to a report published on June 13, 2005, in the
Archives of Internal Medicine,
receive unnecessary antipsychotic prescriptions in doses that are more
than fifty percent of the maximum recommended dosage.
[50] In America, in 2007,
healthcare professionals wrote more than 22.2 million prescriptions for
generic fluoxetine, the third most prescribed antidepressant.
Other
drug makers who produce SSRIs such as Paxil, Prozac (1987), Zoloft
(1992), Celexa, and Luvox began marketing their FDA-approved
antidepressants to treat new diagnosis. Instead of developing a new drug
and going through clinical trials, the companies encourage, through
their sales reps, that physicians write prescriptions for off-label
health issues. The sales of antidepressants increased eight times
between 1990 and 2000. Doctors typically encourage medication instead of
psychotherapy and see more patients per day. Robert L Spitzer, a
recipient of numerous industry grants, headed the committee that decided
to add GAD to the DSM in 1980. In 1998, SmithKline applied for FDA
approval of Paxil for social anxiety disorder (SAD), also found in the
DSM, which the FDA considers “sufficient proof that a disease actually
exists.” The FDA, instead of requiring new drug studies often accept
previously approved drugs without further testing for the new “disease,”
which the drug makers aggressively promote.
[51]
Doctors are prescribing more off-label psychiatric
drugs for children. On April 24, 2005, the
Columbus Dispatch reported
that doctors prescribed psychotropic drugs for 40,000 Medicaid-covered
children aged six to eighteen. Thirty-one percent of these children were
in foster care while twenty-two percent were in juvenile detention. In
2003, Medicaid, fraught with fraud,[52]
spent $65.5 million for psychiatric drugs for children. The FDA
confirmed that doctors wrote eleven million prescriptions for
individuals under the age of nineteen, an increase of twenty-seven
percent in three years. In 2003, according to Medco Health Solution, a
mail-order drug company, doctors increased prescriptions for ADHD drugs,
in the 5 to 9-year-old group by eighty-five percent. For preschool
children, the use of ADHD drugs increased by forty-nine percent. By
2004, according to NDC Health Corp, the sales of psychiatric drugs
amounted to $26.7 billion.
[53]
In 2009, Eli Lilly paid $1.4 billion for the
off-label promotion of Zyprexa. Likewise, Pfizer paid $2.3 billion for
the promotion of Geodon and other drugs. In 2010, Astra-Zeneca paid $520
million for the off-label promotion of Seroquel for children while
Forest Laboratories paid $309 million for the illegal off-label
promotion of Lexapro and Celexa in children. Financial penalties have
not curtailed the drug industry’s aggressive criminal promotions; it is
simply the cost of doing business. These fines satisfy their liability
for these crimes. Psychiatrists and other prescribers continue to
prescribe these drugs for children, especially those in the Medicaid
system, which keeps paying the claims.
[54]
Dr. Beth McDougall said, “What ends up happening is
that someone feels good for a while and then very often they have to
have their dose increased. And then they feel good for a while and then
they might have to have it increased again, or maybe they’ll switch
agents. So it’s that kind of a story, if you’re not actually getting to
the root of what’s going on.”
[55]
Brand names, (generic names): SSRIs
Akarin (citalopram)
Apo-Sertral (sertraline)
Aropax (paroxetine)
Asentra (sertraline)
Celexa (citalopram)
Cipralex (escitalopram)
Cipram (citalopram)
Cipramil (citalopram)
Citopam (citalopram)
Deroxat (paroxetine)
Dumyrox (fluvoxamine)
Eufor (fluoxetine)
Faverin (fluvoxamine)
Floxyfral (fluvoxamine)
Fluctine (fluoxetine)
Fluocim (fluoxetine)
Fluox (fluoxetine)
Fluvox (fluvoxamine)
Gladem (sertraline)
Ladose (fluoxetine)
Lexapro (escitalopram oxalate)
Lovan (fluoxetine)
Lustral (sertraline)
Luvox (fluvoxamine)
Paroxat (paroxetine)
Paxil (paroxetine)
Pexeva (paroxetine)
Prisdal (citalopram)
Prozac (fluoxetine hydrochloride)
Psiquial (fluoxetine)
Reuptake Inhibitors)
Sarafem (fluoxetine hydrochloride)
Sercerin (sertraline)
Serlift (sertraline)
Seroplex (escitalopram)
Seroplexa (escitalopram)
Seropram (paroxetine)
Seroxat (paroxetine)
Sipralexa (escitalopram)
Tolrest (sertraline)
Veritina (fluoxetine)
Xydep (sertraline)
Zoloft (sertraline hydrochloride)
[56]
SNRIs
(Serotonin- Norepinephrine Reuptake Inhibitors)
Ariclaim (duloxetine)
Cymbalta (duloxetine)
Dalcipran (milnacipran)
Dobupal (venlafaxine)
Efectin (venlafaxine)
Effexor (venlafaxine)
Ixel (milnacipran)
Pristiq (desvenlafaxine)
Yentreve (duloxetine)
[57]
Atypical Antipsychotic Drugs Information
Aripiprazole (marketed as Abilify)
Asenapine
Maleate (marketed as Saphris)
Clozapine
(marketed as Clozaril)
Iloperidone (marketed as Fanapt)
Lurasidone (marketed as Latuda)
Olanzapine (marketed as Zyprexa)
Olanzapine/Fluoxetine (marketed as Symbyax)
Paliperidone (marketed as Invega)
Quetiapine (marketed as Seroquel)
Risperidone (marketed as Risperdal)
Ziprasidone (marketed as Geodon) [58]
The FDA
approved Prozac, the first SSRI for adults, in December 1987, and for
children in January 2003.”
[59]
SSRIs Side Effects:
• Abdominal pain
• Akathisia
• All over body pain
• Anxiety
• decreased sex drive
• Diarrhea
• Dizziness
• Drowsiness
• Dry mouth
• Ejaculation problems
• Emotional numbness
• Fatigue
• Flu-like symptoms
• Headache
• Hot flashes
• Impotence
• Indigestion
• Insomnia
• Irritability
• Loss of appetite
• Nausea
• Neck/jaw pain
• Nervousness
• Numbness
• Pins and needles feeling
• Rapid heartbeat
• Shakiness (tremors)
• Slow heartbeat
• Suicide
• sweating
• Tiredness/lack of energy
• Weakness
• Weight gain
• yawning
[60]
Both Prozac (fluoxetine) and Paxil (paroxetine) contain
fluorine and chloride and are drugs that are designed to inhibit the
reuptake of serotonin (SSRI), which interferes with the biological actions
of serotonin, a neurotransmitter. In these drugs, fluoride or
4-fluorophenyl, a compound, is an active ingredient in both Paxil and
Prozac. That same compound is in some pesticides and other products.
Fluorophenyl compounds alter the thyroid hormone activity and the liver in
numerous ways. Patients who take paroxetine experience a reduction in the T4
level. In animal studies, there is a reduction in both the T4 and T3 levels.
[61]
In addition to
their addictive characteristics, an individual taking Paxil, Prozac, Luvox
and other SSRIs need to withdraw from them gradually because of the effects
that these drugs have on the thyroid hormone system. The infants of mothers
who take fluoxetine and breastfeed their infants often experience decreased
development versus those infants whose mothers do not take
fluoxetine. Fluoxetine may also contribute to hepatitis by causing the liver
to dysfunction. It may also cause hyperthyroidism, and visual hallucinations
such as moving images such as frightening flying or swarming translucent
insects.
[62]
Using the
FDA’s Adverse Event Reporting System (AERS) data, Thomas J. Moore, Joseph
Glenmullen, and Curt D. Furberg extracted all of the “serious adverse event
reports” for drugs with 200 or more cases received from 2004 through
September 2009 (69 months), covering 780,169 serious adverse events reports
of all kinds. They identified the events that indicated homicide (387),
homicidal ideation (896), physical assault (404), physical abuse (27) or
violence related symptoms (223) which totaled 1,937 cases of violence
disproportionally associated with thirty-one drugs. The patients were
forty-one percent female and fifty-nine percent male. The top ten are as
follows:
1.Varenicline (Chantix): The number one
violence-inducing drug on the list, this anti-smoking medication is 18 times
more likely to be linked with violence when compared to other drugs
2.Fluoxetine (Prozac): This drug was the first well-known SSRI
antidepressant
3.Paroxetine (Paxil): Another SSRI antidepressant, Paxil is also linked with
severe withdrawal symptoms and a risk of birth defects
4.Amphetamines:(Various brand names): Used to treat ADHD
5.Mefoquine (Lariam): A treatment for malaria which is often linked with
reports of strange behavior
6.Atomoxetine (Strattera): An ADHD drug that affects the neurotransmitter
noradrenaline
7.Triazolam (Halcion): This potentially addictive drug is used to treat
insomnia
8.Fluvoxamine (Luvox): Another SSRI antidepressant
9.Venlafaxine (Effexor): An antidepressant also used to treat anxiety
disorders
10.Desvenlafaxine (Pristiq): An antidepressant which affects both serotonin
and noradrenaline
[63]
Dr. David Healy obtained statistics about Prozac
directly from Eli Lilly and from independent research from which he
estimated that, “probably 50,000 people have committed suicide on Prozac
since its launch, over and above the number who would have done so if left
untreated.”
[64]
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